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Clinical trials for Brain Lesion

The European Union Clinical Trials Register   allows you to search for protocol and results information on:
  • interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC
  • clinical trials conducted outside the EU/EEA that are linked to European paediatric-medicine development

    • EU/EEA interventional clinical trials approved under or transitioned to the Clinical Trial Regulation 536/2014 are publicly accessible through the
    Clinical Trials Information System (CTIS).

    The EU Clinical Trials Register currently displays   43893   clinical trials with a EudraCT protocol, of which   7300   are clinical trials conducted with subjects less than 18 years old.   The register also displays information on   18700   older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006).

    Phase 1 trials conducted solely on adults and that are not part of an agreed paediatric investigation plan (PIP) are not publicly available (see Frequently Asked Questions ).  
     
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    553 result(s) found for: Brain Lesion. Displaying page 1 of 28.
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    EudraCT Number: 2009-013128-22 Sponsor Protocol Number: HE 42/09 Start Date*: 2010-06-29
    Sponsor Name:Hellenic Cooperative Oncology Group
    Full Title: Lapatinib and Whole Brain Radiotherapy for patients with brain metastases from lung and breast tumors. A phase II study of the Hellenic Cooperative Oncology Group (HeCOG).
    Medical condition: Patients with brain metastases from lung and breast tumors
    Disease: Version SOC Term Classification Code Term Level
    12.0 10006128 Brain metastases LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: GR (Completed)
    Trial results: View results
    EudraCT Number: 2021-003716-12 Sponsor Protocol Number: RHNIA-001-2021 Start Date*: 2022-08-24
    Sponsor Name:Rigshospitalet
    Full Title: S-ketamine for cortical spreading depolarisation in patients with severe acute brain injury
    Medical condition: Severe acute brain injury caused by aneurysmal subarachnoid hemorrhage, spontaneous intracerebral hemorrhage or traumatic brain injury.
    Disease: Version SOC Term Classification Code Term Level
    21.1 100000004865 10018061 General anesthesia LLT
    21.1 100000004865 10070731 Electrocorticography LLT
    20.0 100000004852 10056389 Brain damage LLT
    21.0 100000004852 10019529 Hemorrhage brain LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DK (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2009-012338-56 Sponsor Protocol Number: VAS203/II/1/03 Start Date*: 2009-07-10
    Sponsor Name:vasopharm GmbH
    Full Title: AN EXPLORATIVE PHASE IIa STUDY TO ASSESS SAFETY, TOLERABILITY, PHARMACODYNAMICS AND PHARMACOKINETICS OF VAS203 IN PATIENTS WITH MODERATE AND SEVERE TRAUMATIC BRAIN INJURY
    Medical condition: Moderate and severe traumatic brain injury
    Disease: Version SOC Term Classification Code Term Level
    9.1 10060690 Traumatic brain injury LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed) FR (Completed) ES (Completed) AT (Completed)
    Trial results: View results
    EudraCT Number: 2008-001909-41 Sponsor Protocol Number: 5070197 Start Date*: 2008-04-11
    Sponsor Name:Stepani Bendel
    Full Title: Hydrokortisonihoito elinluovutuspotilailla (HYDRO)
    Medical condition: Tutkittavilla on vakava aivovamma ja/tai lukinkalvonalainen verenvuoto, eikä heitä voida parantaa sairaudestaan. Heitä hoidetaan teho-osastolla mahdollisina elintenluovutuspotilaina.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10019587 Hemorrhage subarachnoid LLT
    9.1 10049054 Brain death LLT
    9.1 10052346 Brain contusion LLT
    9.1 10006117 Brain damage (traumatic) LLT
    Population Age: Gender: Male, Female
    Trial protocol: FI (Completed)
    Trial results: View results
    EudraCT Number: 2007-000584-13 Sponsor Protocol Number: ASSENTE Start Date*: 2007-05-15
    Sponsor Name:OSPEDALE MAGGIORE DI MILANO (IRCCS)
    Full Title: Normothermia in patients with acute cerebral damage
    Medical condition: Subarachnoid hemorrhage, traumatic brain injury
    Disease: Version SOC Term Classification Code Term Level
    6.1 10060690 PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2004-002109-58 Sponsor Protocol Number: RSR13 RT-016 Start Date*: 2005-02-14
    Sponsor Name:ALLOS Therapeutics, Inc.
    Full Title: A Phase 3 Randomized, Open-label Comparative Study of Standard Whole Brain Radiation Therapy with Supplemental Oxygen, with or without Concurrent RSR13 (efaproxiral), in Women with Brain Metastases...
    Medical condition: Brain metastases from breast cancer
    Disease: Version SOC Term Classification Code Term Level
    4.0 10027453 4
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: AT (Completed) HU (Completed) GB (Completed) LT (Completed) ES (Ongoing) IT (Completed)
    Trial results: (No results available)
    EudraCT Number: 2007-005693-31 Sponsor Protocol Number: 312021 Start Date*: 2008-03-04
    Sponsor Name:BAYER
    Full Title: Contrast-enhanced MRI examination of cerebral neoplastic enhancing lesions: comparison of diagnostic efficacy of Gd-DOTA 0.5 M and gadobutrol 1.0 M at 0.1 mmol Gd/kg body weight: Intra-individual ...
    Medical condition: patients with cerebral neoplastic lesions
    Disease: Version SOC Term Classification Code Term Level
    6.1 10006131 PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: IT (Completed)
    Trial results: View results
    EudraCT Number: 2008-007350-35 Sponsor Protocol Number: ML 22203 Start Date*: 2009-07-17
    Sponsor Name:ROCHE
    Full Title: A single arm, open-label trial assessing the effect of Capecitabine (Xeloda®) on progression-free survival rate at four months in breast cancer patients with CNS progression after whole brain radio...
    Medical condition: Female breast cancer patients with progression of brain metastasis following WBRT and at least one measurable lesion in the brain (defined as any lesion >1 cm in longest dimension at MRI).
    Disease: Version SOC Term Classification Code Term Level
    9.1 10006128 Brain metastases LLT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: FR (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2013-004244-37 Sponsor Protocol Number: 13HH1824 Start Date*: 2014-02-21
    Sponsor Name:Imperial College London | Imperial College NHS Healthcare Trust
    Full Title: The control of brain networks after traumatic brain injury: a neuroimaging and neuropsychological study of dopamine and cognition
    Medical condition: Traumatic Brain Injury
    Disease: Version SOC Term Classification Code Term Level
    16.1 100000004863 10060690 Traumatic brain injury LLT
    Population Age: Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2006-002813-11 Sponsor Protocol Number: ISRCTN23625128 Start Date*: 2007-01-02
    Sponsor Name:Xytis Pharmaceuticals Sàrl
    Full Title: A phase II randomised, double blind, placebo-controlled, dose finding, safety and tolerability trial of XY2405 as a treatment for traumatic brain injury
    Medical condition: Moderate to Severe Traumatic Brain Injury
    Disease: Version SOC Term Classification Code Term Level
    8.1 10060690 Traumatic brain injury LLT
    Population Age: Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: GB (Prematurely Ended) CZ (Completed) BE (Completed) EE (Prematurely Ended) ES (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2011-006135-29 Sponsor Protocol Number: PH-107 Start Date*: 2012-09-03
    Sponsor Name:Bracco Imaging S.p.A.
    Full Title: PHASE IV, DOUBLE-BLIND, MULTI-CENTER, RANDOMIZED, CROSSOVER STUDY TO COMPARE 0.1 mmol/kg OF PROHANCE® WITH 0.1 mmol/kg OF GADOVIST®/GADAVIST™ IN MAGNETIC RESONANCE IMAGING (MRI) OF THE BRAIN (TRUTH)
    Medical condition: Have confirmed or are highly suspected of brain disease likely to enhance as determined by the following: clinical/neurological symptomatology; diagnostic testing, such as CT or previous MRI exam...
    Disease: Version SOC Term Classification Code Term Level
    15.0 10022891 - Investigations 10029820 Nuclear magnetic resonance imaging gadolinium-enhanced LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: CZ (Completed) IT (Completed)
    Trial results: View results
    EudraCT Number: 2005-005707-42 Sponsor Protocol Number: A090624 Start Date*: 2007-07-23
    Sponsor Name:Cambridge University Hospitals NHS Foundation Trust and University of Cambridge
    Full Title: A single centre phase II study of Interleukin 1 receptor antagonist in the treatment of severe Traumatic Brain Injury
    Medical condition: Severe Traumatic Brain Injury
    Disease: Version SOC Term Classification Code Term Level
    9.1 10060690 Traumatic brain injury LLT
    Population Age: Adolescents, Under 18, Adults Gender: Male, Female
    Trial protocol: GB (Completed)
    Trial results: View results
    EudraCT Number: 2008-007349-30 Sponsor Protocol Number: ML21873 Start Date*: 2009-04-15
    Sponsor Name:ROCHE
    Full Title: Open-label, phase II, randomized, comparative, multicentre trial of concurrent Whole Brain Radiation Therapy (WBRT) and capecitabine (Xeloda®) followed by maintenance capecitabine compared with sta...
    Medical condition: Female breast cancer patients with newly diagnosed CNS metastases with at least one brain lesion measuring ≥0.5 cm in longest dimension, who are not considered candidates for surgery or stereotacti...
    Disease: Version SOC Term Classification Code Term Level
    9.1 10006128 Brain metastases LLT
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: FR (Completed)
    Trial results: View results
    EudraCT Number: 2021-006694-39 Sponsor Protocol Number: ASF-CP02-001 Start Date*: 2022-07-08
    Sponsor Name:Lantmännen Medical AB
    Full Title: An open-label, historical cohort control study to evaluate the safety and tolerability of AF-16 in patients with cerebral oedema caused by traumatic brain injury (TBI)
    Medical condition: Cerebral oedema caused by traumatic brain injury (TBI)
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004863 10060690 Traumatic brain injury LLT
    20.1 100000004852 10008127 Cerebral oedema LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: DE (Completed)
    Trial results: (No results available)
    EudraCT Number: 2018-003994-80 Sponsor Protocol Number: ET18-270 Start Date*: 2019-10-03
    Sponsor Name:Centre Léon Bérard
    Full Title: A Phase II study evaluating AGuIX® nanoparticles in combination with Stereotactic Radiation for oligo brain metastases
    Medical condition: Brain metastases
    Disease: Version SOC Term Classification Code Term Level
    20.0 100000004864 10006128 Brain metastases LLT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2008-001409-40 Sponsor Protocol Number: S334.2.002 Start Date*: 2009-03-04
    Sponsor Name:Solvay Pharmaceuticals B.V.
    Full Title: A Randomized, Double blind, Placebo-Controlled Dose Escalation Study to Investigate the Safety and Pharmacokinetics after Single and Multiple Doses of SLV334 in Sequential Cohorts of Patients with ...
    Medical condition: Moderate and severe Traumatic Brain Injury (TBI)
    Disease: Version SOC Term Classification Code Term Level
    9.1 10060690 Traumatic brain injury PT
    Population Age: Adults, Elderly Gender: Male, Female
    Trial protocol: FR (Completed) ES (Prematurely Ended) IT (Prematurely Ended)
    Trial results: View results
    EudraCT Number: 2020-003391-40 Sponsor Protocol Number: 2020-KEP-456 Start Date*: 2020-12-17
    Sponsor Name:London School of Hygiene and Tropical Medicine
    Full Title: Intramuscular tranexamic acid for the treatment of symptomatic mild traumatic brain injury in older adults: a randomised, double-blind, placebo-controlled trial.
    Medical condition: Mild traumatic brain injury.
    Disease: Version SOC Term Classification Code Term Level
    20.1 100000004863 10060690 Traumatic brain injury LLT
    Population Age: Elderly Gender: Male, Female
    Trial protocol: GB (GB - no longer in EU/EEA)
    Trial results: (No results available)
    EudraCT Number: 2015-002328-24 Sponsor Protocol Number: BRAIN Start Date*: 2015-09-04
    Sponsor Name:UZ Brussel
    Full Title: Evaluation of 68GaNOTA-Anti-HER2 VHH1 uptake in brain metastasis of cancer patients
    Medical condition: brain metastasis lesions from potential HER2 cancer patients
    Disease:
    Population Age: Adults, Elderly Gender: Female
    Trial protocol: BE (Ongoing)
    Trial results: (No results available)
    EudraCT Number: 2011-003669-14 Sponsor Protocol Number: ISRCTN15088122 Start Date*: 2012-12-03
    Sponsor Name:London School Of Hygiene and Tropical Medicine
    Full Title: Tranexamic Acid for the treatment of significant traumatic brain injury: an international, randomised, double blind, placebo controlled trial.
    Medical condition: Traumatic Brain Injury
    Disease: Version SOC Term Classification Code Term Level
    14.1 10022117 - Injury, poisoning and procedural complications 10060690 Traumatic brain injury LLT
    Population Age: Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: ES (Completed) GB (Completed) IT (Completed) IE (Completed) SI (Completed)
    Trial results: View results
    EudraCT Number: 2007-000083-24 Sponsor Protocol Number: GCPL/RGN/02 Start Date*: 2007-06-07
    Sponsor Name:Regen Therapeutics PLC
    Full Title: A survey of efficacy of zolpidem in patients with brain injury including SPECT brain scans in selected patients
    Medical condition: Brain damage of any original cause, such as strokes, trauma, birth injury, post-viral infection.
    Disease: Version SOC Term Classification Code Term Level
    9.1 10056389 Brain damage LLT
    Population Age: Adolescents, Under 18, Adults, Elderly Gender: Male, Female
    Trial protocol: GB (Not Authorised)
    Trial results: (No results available)
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    The status and protocol content of GB trials is no longer updated since 1 January 2021. For the UK, as of 31 January 2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI. Legal notice
    As of 31 January 2023, all EU/EEA initial clinical trial applications must be submitted through CTIS . Updated EudraCT trials information and information on PIP/Art 46 trials conducted exclusively in third countries continues to be submitted through EudraCT and published on this website.

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